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BuSpar is an antianxiety agent that is not chemically or pharmacologically related to the barbiturates , benzodiazepines, or other sedative/anxiolytic drugs. It is a psychotropic drug with anxiolytic properties which is part of chemically to the class of compounds known as the azaspirodecanediones The mechanism of action of buspar is unknown. Buspar differs from typical benzodiazepine anxiolytics drug and it does not exert anticonvulsant or muscle relaxant effects. It also deficient in prominent sedative effect that is associated with more typical anxiolytics.
Buspirone is indicated for the management of the short-term relief of the symptoms of anxiety or anxiety disorders. Tension associated or anxiety with the stress of everyday life usually does not require treatment with an anxiolytic.
The efficacy of this drug has been demonstrated in controlled clinical trials of outpatients whose diagnosis roughly corresponds to Generalized Anxiety Disorder. Many of the patients enrolled in these studies also had precipitating depressive symptoms and Buspar relieved anxiety in the presence of these coexisting depressive symptoms. The patients assessed in these studies had experienced symptoms for periods of 1 month to over 1 year prior to the study, with an average symptom duration of 6 months.
The effectiveness of this drug in long-term use, that is, for more than 3 to 4 weeks, has not been demonstrated in controlled trials. There is no body of evidence available that systematically addresses the appropriate duration of treatment for Generalized Anxiety Disorder. However, in a study of long-term use, 264 patients were treated with Busparfor 1 year without ill effect. Therefore, the healthcare provider who elects to use Buspar for extended periods should periodically reassess the usefulness of the drug for the individual patient.
This drug is not recommended for patients having hypersensitivity to Buspirone hydrochloride and patients with severe hepatic or severe renal impairment.
The administration of Buspar to a patient taking a monoamine oxidase inhibitor may pose a potential danger. There have been reports of the occurrence of elevated blood pressure when this drug has been added to a regimen including an MAOI.